Genes such as CD28 (T-cell co-stimulation), CCL20 and CCR6 (T-cell migration), NFATC1 (lymphocyte proliferation), NFKBIZ (Th17 development) associated with T-cell function demonstrate the potential for therapeutic strategies, which target different stages of T-cell involvement in IBD, such as recruitment, activation, proliferation, and retention. The gene discussed is CCL20; the disease is inflammatory bowel disease.