Dephosphorylated cofilin promotes actin cytoskeleton reorganization by depolymerizing F-actin, stimulates actin turnover and, which augments the lamellipodium formation and extension, promote the cancer metastasis (Ghosh et al., 2004; Chan et al., 2009; Bravo-Cordero et al., 2013). The gene discussed is CFL1; the disease is cancer.