The mRNA levels and expression of cofilin were significantly increased in tumor tissues than in benign prostatic hyperplasia tissues or normal tissues, this was a common phenomenon that observed in various types of cancer, such as hepatoblastoma (Liu et al., 2018), breast cancer (Maimaiti et al., 2017), non-small cell lung cancer (Wei et al., 2012), prostate cancer (Collazo et al., 2014; Lu et al., 2015), colorectal cancer (Sousa-Squiavinato et al., 2019), vulvar squamous cell carcinoma (Wu et al., 2016), ovarian cancer (Chen et al., 2014), and bladder cancer (Wang et al., 2017). The gene discussed is CFL1; the disease is breast cancer.