CFL1 and cancer: The overexpression of LIMK1 phosphorylated cofilin and supressed the cancer metastasis by suppressing of lamellipodium formation, while mutated LIMK1 increases the motility of tumor cells (Meyer et al., 2005; Li Z. et al., 2014), similar results were observed in studies of LIMK2 (Collazo et al., 2014; Xu et al., 2019).