TRPM8 and Familial prostate cancer: For example, TRPV1 is increased in prostate, colon and pancreas cancer cells, and TRPM8 has been found in breast, colon, lung and prostate cancer cells (Clapham, 2003; Prevarskaya et al., 2007; Wondergem et al., 2008; Wondergem and Bartley, 2009; Shapovalov et al., 2011; Bauer et al., 2012).