Although Zhang and Barritt (2004) reported TRPM8 expression in PM and ER of the prostate cancer-derived epithelial cell line (LNCaP)s, Thebault et al. (2005) found that the expression was restricted to ER, where it participated in Ca2+ store depletion after cold or menthol stimulation. Here, TRPM8 is linked to Familial prostate cancer.