TRPM8 and retinoblastoma: TRPM8 channels are also expressed and upregulated in some tumors including breast, lung and pancreatic carcinoma as well as glioblastoma, retinoblastoma and uveal melanoma cells (Nilius, 2007; Chodon et al., 2010; Yee et al., 2010; Mergler et al., 2012, 2014; Journigan and Zaveri, 2013).