So we considered that the SNP 1196C>A may not affect the m6A methylation of IGFBP2. In contrast to the high m6A methylated genes, the genes with low m6A peaks (fat line vs. lean line) were primarily related to developmental-associated processes, such as cardiovascular system development (Figure 5C), further reinforcing the theory that there is a close relationship between abdominal obesity and cardiovascular disease (Sahakyan et al., 2015). The gene discussed is IGFBP2; the disease is cardiovascular disorder.