LHCGR and neoplasm: Casadesus et al. (2007) described that increased LH levels are associated with declines in cognitive performance. Human chorionic gonadotrophin (hCG), which shares the α-subunit with LH and acts through the same LHR receptor (Choi and Smitz, 2014), increases gastric cancer cell proliferation through the PKA/c-Met signaling pathway (Zhao et al., 2018). Regarding LHR, its overexpression in endometrial cancer cells increases invasiveness, tumor development, and distal metastasis (Pillozzi et al., 2013).