Therefore, as a first approach to establish the extragonadal actions of LH on BC cell motility, T-47D cells were treated with follicular-phase levels of LH (5 mIU/ml) for different times (0–60 min) to analyze the expression and phosphorylation of N-WASP, a key regulator of actin cytoskeleton reorganization (Frugtniet et al., 2015). The gene discussed is PLOD1; the disease is breast cancer.