Ectopic expression of CHMP2B disrupts autophagy and is associated with frontotemporal dementia (Lee and Gao, 2009), whereas dominant mutations in CHMP2B (CHMP2BIntron5) are associated with a subset of heritable frontotemporal dementia (Krasniak and Ahmad, 2016). This evidence concerns the gene CHMP2B and frontotemporal dementia.