For instance, expression of 1p/19q genes is a potential prognostic marker in 1p/19q non-codeletion gliomas, whereas isocitrate dehydrogenase (IDH) levels have prognostic value in wild-type IDH gliomas (Calvert et al., 2017; Chai et al., 2019a). Here, IDH3A is linked to central nervous system cancer.