There are various cellular processes such as survival, proliferation, growth, metabolism, angiogenesis, and metastasis that can be regulated by the hyperactivated or altered PI3K/Akt/mammalian target in the rapamycin (mTOR) signaling pathway in many cancer types (Katso et al., 2001; Engelman et al., 2006; Martini et al., 2014). The gene discussed is MTOR; the disease is cancer.