Numerous studies have showed that PTL suppresses tumor-promoting effects of nicotine in lung cancer through inducing p53-dependent apoptosis (Talib and Al Kury, 2018), adjusts mitochondrial autophagy induced by oxidative stress, and plays an inhibitory role in the apoptosis of C2C12 myoblasts via the p53 signaling pathway (Ren et al., 2019). The gene discussed is TP53; the disease is lung cancer.