Furthermore, when inoculated in a mouse model of graft versus host disease, UC-MSC EVs were able to reduce the serum level of inflammatory cytokines IL-2, TNFα, and IFNγ, increase the amount of IL-10, and reduce the absolute number of cytotoxic CD8 T lymphocytes (Wang et al., 2016). This evidence concerns the gene CD8A and graft versus host disease.