CMTM4 and neoplasm: In SW480 cells, CMTM4 expression was found to be inversely related to the phosphorylation of AKT1, and the tumor-suppressive functionalities observed with CMTM4 overexpression could be mimicked in the CMTM4- SW480 cell line by direct chemical inhibition of AKT using LY294002 (Xue et al., 2019).