Our data indicated the high carriage of erm(A) in linezolid-resistant/intermediate E. faecalis UTI isolates and three linezolid-resistant E. faecalis isolates were positive with optrA. The mechanism of erm(A) that participate in macrolide or clindamycin resistance is mainly mediated by methylating the V domain of 23S rRNA gene. The gene discussed is ETV5; the disease is bacterial urinary tract infection.