In this line, recent studies have shown that the lack of deletions involving CDKN2A/ARF/CDKN2B locus, combined with undetectable MRD (≤ 0.01%) values, allowed the identification of a subset of adult T-ALL patients with better OS in the absence of allo-SCT (31). The gene discussed is CDKN2B; the disease is acute lymphoblastic leukemia.