RBL2 and cancer: LncRNA BZRAP1-AS1 was found not only was it crucial in the primary functional regulatory network, but also it was the node with the maximum degree in the metastatic functional regulatory gain network, and was critical for cancer metastasis, influencing the three functions by means of interacting with PIP4K2A, TP53INP1, RRAGD, TBC1D9, and RBL2. Furthermore, we found six among seven lncRNAs that regulating metastasis-related functions in LUAD also regulated cancer-related functions in the primary functional regulatory network.