We found that HOXA11-AS was continuously up-regulated in LUAD carcinogenesis as well as metastasis and regulated the expression of E2F2 and SENP5 by way of competing for miRNAs in the primary functional regulatory network to influence cell cycle, implying that HOXA11-AS was closely related to lung cancer carcinogenesis. This evidence concerns the gene SENP5 and lung carcinoma.