For example, MALAT1 was significantly highly expressed in non-small cell lung cancer(NSCLC) with bone metastasis and in NSCLC cell lines with high bone metastatic ability (8); An lncRNA, actin filament associated protein 1 antisense RNA1 (AFAP1-AS1), was the most significantly upregulated in lung cancer and associated with poor prognosis (9). The gene discussed is AFAP1; the disease is lung carcinoma.