Furthermore, the majority of mRNAs involving in the primary or metastatic functional regulatory gain network had been shown the association with cancer, such as TP53INP1 among the 14 mRNAs involving in the metastatic functional network had been shown in various studies concerning hepatocellular carcinoma and colorectal cancer (60, 61). Here, TP53INP1 is linked to hepatocellular carcinoma.