In primary or metastatic cancer, mRNAs IGF2BP3, HOXA9, HOXA10, CEBPG competed with HOXA11-AS mutually, and HOXA10 (Figure 6B) as well as IGF2BP3 (Figure 6C) were also continuously up-regulated among normal-primary-metastatic process with significant difference in variance analysis. The gene discussed is HOXA11; the disease is metastatic malignant neoplasm.