To evaluate the effect of TCO on lung cancer growth in vivo, A549 andcA549 cells transfected with pcDNA3.1-Trop2 (or H1299 and H1299 cells transfected with pcDNA3.1-Trop2) were implanted subcutaneously in BALB/c nude mice and treated with TCO or DMSO. This evidence concerns the gene TACSTD2 and lung cancer.