in a mouse model of HPV-associated HNSCC suggests that the combination of radiation and PD-1 inhibition also promotes maturation and activation of B-cells, leading to the development of memory B-cells, plasma cells, and antigen-specific B-cells, as well as increasing formation of B-cell germinal centers in tumor draining lymph nodes (40). The gene discussed is PDCD1; the disease is head and neck squamous cell carcinoma.