demonstrated in an syngeneic mouse model of oral cavity cancer that 20 Gy in 10 fractions compared to 16 Gy in 2 fractions to both the primary tumor and the draining lymph nodes blunted tumor-specific CD8+ T-cell responses within those draining lymph nodes (although notably tumors were implanted in the mice legs and thus this is not a perfect model for head and neck lymphatics) (47). This evidence concerns the gene CD8A and neoplasm.