TP53 and cancer: Although apoptosis seems as the main route, inhibiting the HDACs, for example by the suberoylanilide hydroxamic acid (SAHA), a pan HDAC inhibitor, is shown to induce the destabilization of the HDAC6–HSP90–mutp53 complex (165), that results in mutant p53 degradation in cancer cells with pronounced autophagy induction, such as in MDA-MB-231 bearing the mutant p53R280K (164).