While, a direct interference of p53R175H, R273H mutants on MA can be denoted to LOF transcriptional repression of core autophagy genes (BECN1, ATG12) (91), most of the mutant p53-mediated autophagy inhibitory evidence stems from studies describing a gained regulatory effect of mutants on cancer metabolism (Figure 1). The gene discussed is BECN1; the disease is cancer.