TP53 and cancer: It is further important to consider that although few missense substitutions (Arg175, Gly245, Arg248, Arg273, and Arg282) account for about 30% of all TP53 mutations, there are more than 1,500 types of p53 mutations reported in various cancer types (http://p53.iarc.fr/), and different mutant variants are frequently detected in different human cancers (6).