In our study, AUROC of AFP ratio could also predict tumor response differentiating CR+PR from PD (AUC, 0.833; 95% CI, 0.69–0.98, Figure 4Ai), CR from PR+PD (AUC, 0.764; 95% CI, 62.0–91.0, Figure 4Aii), and CR from PD (AUC, 0.853; 95% CI, 0.70–1.0, Figure 4Aiii). This evidence concerns the gene AFP and neoplasm.