Prediction of tumor response to differentiate CR+PR from PD, group 1 (Figure 4Ai) using serum AFP ratio alone in ROC curve of AFP producer group (n = 45) had shown AUC 0.833 (95% CI, 0.69–0.98) at a cut off 1.23 with 80.0% (95% CI, 51.9–95.7) sensitivity and 88.5% (95% CI, 69.9–97.6) specificity. The gene discussed is AFP; the disease is neoplasm.