ScRNA-seq data also revealed that the known nuclear hormone receptor retinoic-acid-receptor-related orphan receptor gamma (RORγ) in pancreatic cancer stem cells which drives T cell differentiation is up-regulated during the progression of tumor and its pharmacological inhibitory effect leads to significant defect in the growth and increase in survival rate of pancreatic cancer (14). The gene discussed is RORC; the disease is familial pancreatic carcinoma.