FOXP3 and primary cutaneous T-cell non-Hodgkin lymphoma: In addition, scRNA-seq analysis has observed FOXP3 + malignant T cells and GATA3 + or IKZF2 +(HELIOS)tumor cells that are transformed from FOXP3 + T cells during cloning and evolution of Sézary, an aggressive form of cutaneous T-cell lymphoma (52).