found that the intensity of glycolysis metabolites declined in CD8+ TILs while the peroxisome proliferator-activated receptor (PPAR)-a signaling and fatty acid (FA) catabolism metabolites increased, implying that CD8+ TILs switched to these modes of metabolism to preserve their effector functions under the pressure of hypoglycemia and hypoxia in TME. The gene discussed is CD8A; the disease is Hypoglycemia.