Importantly, alteration in MGMT in MGMT-deficient glioblastoma cells has been implicated in acquired TMZ resistance in several ways, including modulation of DIP2A/MGMT signaling by Fstl1 (19), IKBKE-induced upregulation of MGMT (20) and regulation of MGMT expression by miRNAs resulting in degradation of MGMT mRNA before translation (21). Here, MGMT is linked to glioblastoma.