MGMT and glioblastoma: Unfortunately, Phase 3 clinical trials with nivolumab in newly diagnosed glioblastoma patients with unmethylated MGMT promoter status (CheckMate-493; NCT02617589) combined with radiation therapy (99), and in patients with methylated MGMT promoter status (CheckMate-548; NCT02667587) (100) combined with standard of care radiation therapy and TMZ (vs. standard of care treatment) failed to demonstrate a significant improvement in OS in CheckMate-498, and failed to meet the PFS primary endpoint in CheckMate-548.