Of the 15 genes, LAMC2 (39–41), SERPINE1 (41–43), PLAU (44), MYO1B (45), LAMB3 (46), CEACAM1 (41, 47), CEACAM6 (48, 49), ALDH3A1 (50) and SPINK5 (51) has been reported as HNSCC prognostic markers, and in this study, we first uncovered the clinical significance of SEMA3C, FAP, COBL, DUSP5, ENDOU and METTL7A with HNSCC survival. The gene discussed is SPINK5; the disease is head and neck squamous cell carcinoma.