Of the 15 genes, LAMC2 (39–41), SERPINE1 (41–43), PLAU (44), MYO1B (45), LAMB3 (46), CEACAM1 (41, 47), CEACAM6 (48, 49), ALDH3A1 (50) and SPINK5 (51) has been reported as HNSCC prognostic markers, and in this study, we first uncovered the clinical significance of SEMA3C, FAP, COBL, DUSP5, ENDOU and METTL7A with HNSCC survival. This evidence concerns the gene ENDOU and head and neck squamous cell carcinoma.