Sirtuins are a family of Nicotinamide Adenine Dinucleotide (NAD+)-dependent histone deacetylases (HDAC) and, thus, are referred to as class III HDAC [10-13]. They catalyze the deacetylation of lysine residues in histone and non-histone proteins [11]. An increasing number of studies suggest a possible health benefit in cardiovascular diseases via regulating cellular metabolism, cell cycle, cellular senescence, apoptosis, and genomic stability [14-17]. Here, HDAC9 is linked to cardiovascular disorder.