NFKB1 and atherosclerosis: Kawahara et al. showed that SIRT6 alters NF-kB expression by deacetylation of H3K9 histone, halting the association between the NF-kB RELA (Rel associated protein) subunit and the promoters in its target gene, hence decreasing inflammation [39]. A combination of inflammation, cellular senescence, and high LDL cholesterol can begin a vicious cycle in atherosclerosis development, which can be stalled by SIRT6.