CDC45 and cancer: Although it has been reported that CDC45 is a proliferative marker in some cancers, there are also reports stressed that the high expression of CDC45 may lead to severe replication pressure, subsequently occurring S-phase arrest, and eventually lead to cellular apoptotic cell death, inhibiting the degradation of CDC45 might be a promising way to combat cancer (Köhler et al., 2016; Zhang et al., 2016).