In response to DNA in the cytoplasm in viral and bacterial infection, the sensor AIM2 recruits ASC and Casp1 to form the AIM2 inflammasome complex, which also leads to the autocleavage of Casp1 to generate Casp1 p10 and p20 (Guo et al., 2015; Lamkanfi & Dixit, 2012). The gene discussed is AIM2; the disease is bacterial infectious disease.