Hence, the molecular signature of MTEX consisting of PDCD6IP/ALIX, 4 correlated proteins (HSP90AB1, TUBB, TUBB1, and PFN1) highly expressed in MTEX of patients with PD, plus CNTN1 and TGF‐β1 with differential distribution in MTEX of PD vs NED/SD patients may have prognostic significance in melanoma. Here, HSP90AB1 is linked to melanoma.