VEGFA and neoplasm: These findings explain that irradiation, DNA damage, cell death, and hypoxia stimulate tumors to produce vascular endothelial growth factor (VEGF), stromal cell-derived factor 1α (SDF-1α), and colony-stimulating factor 1 (CSF-1), which are involved in the recruitment of macrophages to the tumor [122–126] (Figure 1).