Among the inflammasomes, NATCH, LRR, and PYD domain-containing protein 3 (NLRP3) is well characterized [2] and is associated with several human disorders such as Alzheimer's disease, obesity, rheumatoid arthritis, asthma, nonalcoholic fatty liver disease, and autoimmune encephalitis [3]. The gene discussed is NLRP3; the disease is early-onset autosomal dominant Alzheimer disease.