In osteosarcoma cells, the expression levels of BAX and BIM levels can be suppressed by a transcriptional complex assembled by a corepressor CtBP1 (Carboxyl-terminal binding protein 1), the p300 histone acetyltransferase, and the Forkhead box O3 (FOXO3a) transcription factor 7. Here, BCL2L11 is linked to osteosarcoma.