For MF, the enrichment result indicated BRAFV600E-associated genes were not only enriched in binding to sulfide and heparin but also played a certain role in the activity of receptor kinases and tyrosine kinases, which has been confirmed in a variety of BRAF mutant tumors, including thyroid cancer, colorectal cancer, melanoma, etc26-30. This evidence concerns the gene BRAF and thyroid cancer.