ITGA5 and familial pancreatic carcinoma: In present study, according to the results from Figure 1, after the treatment with SW1990-CM, ITGA5 expression in PSCs has a significant increase, meaning that PSCs activation occurred and our used pancreatic cancer xenografts, which were established by the co-injection of cancer cells and PSCs, would have a high expression of ITGA5 in the tumor stroma or the activated PSCs.