ITGA5 and neoplasm: Our used pancreatic cancer animal model, which was established via cancer cells injection alone and the co-injection of cancer cells and PSCs in the same nude mouse, not only reflected the pro-tumorigenic effect of PSCs, but also confirmed that the existence of PSCs made the xenograft tumor has a higher ITGA5 expression and ITGA5-expressing PSCs rather than cancer cells had an effective uptake of 125I-AV3, suggesting the feasible of pancreatic cancer imaging by targeting CAFs or the activated PSCs.