125I-AV3 SPECT/CT imaging of pancreatic cancer-bearing nude mice showed that the radiotracer was mainly accumulated in the right tumor, and the xenografts tumor in the left lower limb has a very weak imaging, suggesting that 125I-AV3 can target the ITGA5-expressing PSCs rather than cancer cells (Figure 3A). This evidence concerns the gene ITGA5 and pancreatic neoplasm.