Korehisa et al. confirmed that PDL1, CD68+ M, and CD8+ T cell levels at the invasion frontier region were significantly higher than those in the tumor center of MSI-H colon cancer, and PDL1 was expressed in tumor cells and CD68+/CD163+ (M2) M at the invasion front of MSI-H colon cancer 39. This evidence concerns the gene CD8A and malignant colon neoplasm.