Based on our observation that OCT1 was the most highly expressed OCT transcription factor in ESCC specimens and our previous finding that higher levels of OCT4 were significantly associated with higher tumor grade in ESCC 10, we examined the correlation between OCT1 and OCT4 expression and clinicopathologic characteristics of the tumors specimens. The gene discussed is PLXNA2; the disease is esophageal squamous cell carcinoma.