On the basis of previous studies of tumor biology, Eckel-Passow JE et al. proposed five molecular groups according to the three biomarkers: triple-positive (mutations in both TERT and IDH plus 1p/19q codeletion), mutations in both TERT and IDH, mutation in IDH only, mutation in TERT only, and triple-negative 9. The gene discussed is TERT; the disease is neoplasm.