The results of gene enrichment analysis, which was performed using GSEA, KEGG, Reactome, and Funrich databases, showed that these genes were mainly involved in the inflammatory response, TNF-α signaling via NF-κB, interferon signaling pathway, IL-6/JAK/STAT3 signaling and chemokine receptors bind chemokines, revealing that immune response and inflammatory response play critical roles in pathogenesis of psoriasis. The gene discussed is TNF; the disease is psoriasis.