It is well-documented that palmitic acid is associated with obesity, with decreased insulin sensitivity that could increase risk of type 2 diabetes and higher cardiovascular disease risk through increased level of blood cholesterol much more of other SFAs (Mensink et al., 2003; Bermudez et al., 2014; Praagman et al., 2016; Imamura et al., 2018). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.