As a result, we noticed that a higher expression of REN (HR = 0.5; CI = 0.37–0.69; log-rank p = 1.6e-05), OGDHL (HR = 0.46; CI = 0.34–0.63; log-rank p = 5.7e-07), and HSD11B2 (HR = 0.53; CI = 0.39–0.72; log-rank p = 3e-05) was associated with the improved overall survival in ccRCC patients. Here, HSD11B2 is linked to nonpapillary renal cell carcinoma.