Moreover, it has been shown that the strong over-expression of sulfate transporters triggered by S deficiency (Maruyama-Nakashita et al., 2004) leads to an increased uptake of Mo and Se in the form of MoO42– and SeO42–, respectively (Shinmachi et al., 2010; Maillard et al., 2016a), as also found in this study (Figure 3). The gene discussed is SLC26A2; the disease is hyperinsulinemic hypoglycemia, familial, 4.