This can be difficult for rare populations, such as pediatric vasculitis, but our preliminary data suggest that, despite the lack of a correlation with markers of systemic disease activity (pVAS, CRP, ESR), LAMP-2-ANCA titers at diagnosis were negatively correlated with the change in GFR (from diagnosis to 12-months), a marker of renal function. The gene discussed is CRP; the disease is vasculitis.