LAMP2 and kidney disorder: The prospect of evaluating LAMP-2-ANCA for direct role(s) in the pathogenesis of renal disease associated with vasculitis or as a biomarker of glomerular damage (13) is inviting, particularly in children with AAV that, compared to adult-onset disease, present with more severe disease involving multiple organs (19, 26) and more than half of patients experience kidney damage early in disease course (27).