CD8A and Autoimmunity: Moreover, both humoral and cellular autoimmunity, altered CD4+/CD8+ T cell ratio, decreased regulatory T cells (Tregs) function, presence of autoreactive anti-melanocyte CD8+ T cells in both blood and skin, as well as imbalance of pro- and anti-inflammatory cytokine levels are reported to be involved in vitiligo pathogenesis (2, 13–20).