A study by Rossi et al. showed that deletion of PD-L1 attenuated the rise in hepatic dysfunction indices including serum bilirubin, alanine aminotransferase (ALT) and aspartate amino transferase (AST) and protected the endothelial permeability barrier, which was associated with improved systemic bacteria clearance and improved survival in a murine model of CLP-induced sepsis (30). Here, CD274 is linked to Sepsis.