2B4+ T cells from septic patients showed increased caspase-3/7+ apoptotic T cells, and 2B4 deletion reduced caspase-3/7+ apoptotic T cells in a murine CLP model of sepsis, thereby implicating 2B4 as an important mediator of sepsis-induced T cell apoptosis (34). This evidence concerns the gene CASP3 and Sepsis.