The inhibitory effects of PD-1:PD-L interaction has been well documented in sepsis-induced T cell exhaustion using PD-1 and PD-L1 blocking antibodies (18, 25, 26), However, specific details about the intracellular signaling pathways executing the PD-1:PD-L interaction driven inhibitory signals are yet to be fully characterized in the context of sepsis. This evidence concerns the gene PDCD1 and Sepsis.