Inflammatory cytokine production is negatively regulated by RvE1 (16, 20, 23), RvD1 (20, 38, 40–42), RvD2 (20, 38), RvD3 (71), and MaR1 (38, 78–80). RvE1, RvD1, and RvD2 suppress chemokine (C-C motif) ligand 4 (CCL4), CCL5, interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α induced by human monocyte-derived macrophages co-cultured with tumor cell debris (20), IL-12 by DCs stimulated with pathogen extract (23), and superoxide production by macrophages stimulated with cigarette smoke (16). The gene discussed is CCL4; the disease is neoplasm.