A global cohort analysis revealed that although mutations in TNFRSF13B are prevalent in CVID and healthy populations, there is an excess of rare derived alleles of TNFRSF13B in CVID cohorts compared to healthy individuals of the same population, indicating that defects in TACI are contributory toward manifestations of CVID (80). Here, TNFRSF13B is linked to common variable immunodeficiency.