Similarly, patients with genetic deficiency of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) or a protein vital for its vesicular trafficking, lipopolysaccharide (LPS)-responsive and beige-like anchor protein (LRBA), develop inflammatory complications that are responsive to CTLA-4-Ig, known as abatacept (21, 22). The gene discussed is CTLA4; the disease is hyperinsulinemic hypoglycemia, familial, 4.