For example, TCF7 and LEF1, that are crucial for establishment of central memory CD8 T cells, were downregulated, respectively, by 1.6-, 1.6-, 2.7-fold and by 1.6-, 1.8-, 4.3-fold, in AC/HS, AD/HS, and ACLF/HS (Table S6). The gene discussed is LEF1; the disease is Alzheimer disease.