CD4 and Increased total leukocyte count: The key results were that patients with ACLF had dysregulation of certain circulating immune cells, including leukocytosis fueled by increased populations of neutrophils (that had unique phenotype) and macrophages M0-like monocytes, and, as expected (31, 32), decreases in lymphocyte count related to a depletion in memory lymphocytes (of the B-cell, CD4 T-cell lineages), CD8 T cells and NK cells.