It was reported that NK cells could contribute to the accumulation of T-bet+ CD4+ T cells in the tumor site, promote the production of TNF-αand IFN-γ by tumor infiltrating CD8+T cells, suppress the expression of exhaustion marker PD-1 on these CD8+ T cells and promote the induction of tumor-specific T cell memory in the mouse model. The gene discussed is CD4; the disease is neoplasm.