Mechanically, hepatocellular carcinoma (HCC) can secreted circUHRF1 in an exosomal manner, inhibiting the secretion of NK cell-derived IFN-γ and TNF-α and inhibiting NK cell function by up-regulating the expression of TIM-3 through degradation of miR-449c-5p (124). Here, HAVCR2 is linked to hepatocellular carcinoma.