Among the known human chemokines, a co-regulated set of four (chemokine (C-C motif) ligand (CCL)-4, CCL-5, chemokine (C-X-C motif) ligand (CXCL)-9, CXCL-10) chemokines is upregulated in primary PDA carcinoma and PDA liver metastasis, which regulates CD8+ T cell infiltration, activates T cells, and promotes NLRP3-mediated T cell priming and enhances anti-tumor CD8+ T cell cytotoxic activity for an effective immune checkpoint therapy response. Here, NLRP3 is linked to Patent ductus arteriosus.