Since the TME possesses hypoxic and inflamed sites that accumulate with extracellular ATP, the impacts of NLRP3 inflammasome on the progression of tumor and maintenance of TME have become a critical issue. Herein, we discuss the emerging literature and highlight the role of NLRP3 in oncogenic development by dissecting the functions and justifying each cancer hallmark to gain a comprehensive understanding. This evidence concerns the gene NLRP3 and neoplasm.