NLRP3 and neoplasm: pointed out that NLRP3 is overexpressed in non-small cell lung cancer (NSCLC) tumor tissues, while in contrast, depletion of NLRP3 reduces cell growth in vitro and in vivo as well as decreases glycolysis while enhancing mitochondrial respiration, where pathways contributing to ATP production and intermediate substrates metabolism serve as the Warburg effect switch (83).