The activation of NLRP3 inflammasome in breast CAF promotes tumor metastasis by upregulating the expression of adhesion molecules in EC and promoting the recruitment of MDSCs, suggesting that IL-1β secretion from activated mammary CAFs enhances the expression of adhesion molecules on tumor EC in vivo, thus facilitating cancer cell migration across the blood vessel endothelium (23). This evidence concerns the gene NLRP3 and cancer.