Besides, in an animal model lacking T, B, and NKT cells, Rag1−/− mice exhibit a similar tumor metastatic burden compared to wild-type mice; however, Rag1−/−/IL-18−/− mice presented with an increased metastatic burden, indicating that IL-18-induced tumor cytotoxicity is independent of the major adaptive immunity effectors such as cytotoxic T lymphocytes (45). The gene discussed is IL18; the disease is neoplasm.