TGFB1 and colorectal carcinoma: Adding a layer of complexity into the intracellular crosstalk, NF-κB signaling has also been proposed to act upstream of NLRP3 where NF-κB is required for the upregulation of NLRP3 in transforming growth factor-beta 1 (TGF-β1)- or TNF-α-induced EMT in CRC (100) (Table 4).