To determine the functional role of CCR8 in the development of intestinal inflammation in mice, microbiota-normalized wildtype control and Ccr8-deficient (Ccr8−/−) mice were administered with DSS in drinking water for 7 days, a model resembling many features of ulcerative colitis in humans (Figure 1C) (23). This evidence concerns the gene CCR8 and ulcerative colitis.