Nigericin and combination of LPS with Nigericin (LPS/Nigericin) increased NLRP3 protein expression in all tumor cell lines as compared to untreated tumor cells and in Nigericin and LPS/Nigericin treated fibroblasts as compared to untreated fibroblasts (Figures 1A–C and Supplementary Figures 1A–C). This evidence concerns the gene NLRP3 and neoplasm.