Together, type I IFNs (innate response) and the adaptive immune responses enhanced by LMP1 [current study and (70, 113, 114, 116)] can contribute to T cell-mediated antibody/autoantibody production, facilitating cross-reactive responses between molecular mimic EBNA-1 and lupus autoantigens (35) (Figure 11-4). The gene discussed is PDLIM7; the disease is systemic lupus erythematosus.