In a mouse model of lupus-like disease that associates phenotype with genetic risk [B6.Sle1.Sle2.Sle3 mice (107)], we have previously demonstrated that mCD40-LMP1 Tg mice accelerate lupus-like autoimmunity in B6.Sle1, but not B6.Sle3 mice [mCD40-LMP1 Tg mice are phenotypically similar to B6.Sle2 mice (71, 107)], including histologic evidence of glomerulonephritis) (69). The gene discussed is PDLIM7; the disease is Autoimmunity.