TRIM21 and systemic lupus erythematosus: In addition to our findings in the current study, we and others have demonstrated cross-reactivity between EBNA-1 and lupus autoantigens, both in animal models and human SLE patients, including Ro/SSA (19, 39, 40, 86), Sm (19, 39, 44, 121), RNP (39, 51, 86), and dsDNA (39, 40, 42–44).