Genetic studies have shown that TNFAIP3 polymorphisms are associated with several autoimmune diseases such as systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), multiple sclerosis (MS), rheumatoid arthritis (RA), and psoriasis (8, 13–33). This evidence concerns the gene TNFAIP3 and systemic lupus erythematosus.