Genetic studies also showed that various A20/TNFAIP3 polymorphisms confer risk of autoimmune disease, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjögren’s syndrome(SS), Crohn’s disease, psoriasis, type1 diabetes, and coeliac disease (8, 12–30, 33, 47). The gene discussed is TNFAIP3; the disease is autoimmune disease.