Genetic studies also showed that various A20/TNFAIP3 polymorphisms confer risk of autoimmune disease, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjögren’s syndrome(SS), Crohn’s disease, psoriasis, type1 diabetes, and coeliac disease (8, 12–30, 33, 47). This evidence concerns the gene TNFAIP3 and rheumatoid arthritis.