C3AR1 and graft versus host disease: Blockade of C3aR/C5aR activation significantly enhanced mitophagy in recipient dendritic cells which correlated with improved GvHD outcomes and the studies also showed that treatment with C3aR/C5aR antagonists effectively separated GvHD and GvL responses making it a promising therapeutic approach for GvHD treatment especially in malignant diseases dependent on the GVL effect (29, 30).