LRBA and hyperinsulinemic hypoglycemia, familial, 4: Many other primary immunodeficiencies with prevailing lymphoproliferation, such as LPS-responsive beige-like anchor protein (LRBA) deficiency and cytotoxic T lymphocyte antigen-4 (CTLA-4) haploinsufficiency, are also associated with decreased or dysregulation of Tregs (55, 56).